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Literature summary extracted from
- The role of copper transporter ATP7A in platinum-resistance of esophageal squamous cell cancer (ESCC) (2016), J. Cancer, 7, 2085-2092 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 7.2.2.8 | medicine | cisplatin-resistant cell sublines show cross-resistance to carboplatin and oxaliplatin. ATP7A expression in cisplatin-resistant cell sublines is much higher than in cisplatin-sensitive cell lines at both mRNA and protein levels. ATP7A-targeted siRNA in cisplatin-resistant cancer cells partially reverses cisplatin-resistance. It also increases cell apoptosis at different cisplatin concentrations | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.8 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.8 | EC-109 cell | - |
Homo sapiens | - |
| 7.2.2.8 | esophageal squamous cell carcinoma cell | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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